EFFECT OF PLYOMETRIC TRAINING ON SPEED AND CHANGE OF DIRECTION ABILITY IN ELITE FIELD HOCKEY PLAYERS


Metabolomic profiling and biomarker identification for early detection and therapeutic targeting of doxorubicin-induced cardiotoxicity

BackgroundDoxorubicin (DOX) is a widely used chemotherapeutic agent known for its efficacy against various cancers, but its clinical application is often limited by its cardiotoxic effects.The exact mechanisms of DOX-induced cardiotoxicity remain unclear, requiring further investigation.Early diagnosis is essential to enhance the quality of life an

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The distribution of a germline methylation marker suggests a regional mechanism of LINE-1 silencing by the piRNA-PIWI system

Abstract Background A defense system against transposon activity in the human germline based on PIWI proteins and piRNA has recently been discovered.It represses the activity of LINE-1 elements via DNA methylation by a largely unknown mechanism.Based on the dispersed distribution of clusters of piRNA genes in a strand-specific manner on all human c

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